L-Theanine Beneifts on Brain

L-Theanine is an amino acid found almost exclusively in green tea.  L-Theanine is known to produce its anti-anxiety effects without producing sleepiness or impairing motor behavior.
Discoveries during the recent years added more benefits on brain.  
1. L-Theanine protects brain cells and promotes cognitive function*.  
2. L-Theanine reduces the elevation of stress hormones and oxidative damage to brain**.  
Stress significantly reduces performance and memory and increases oxidative stress in brain and elevates levels of stress-response hormones.  During the test, treating animals with L-theanine before the stress is applied, results were in reversal, in both cognitive and stress hormones, and oxidative damage.
3. L-Theanine lowers stroke risk and the damaging effects if a stroke has occurred.  
L-Theanine provides two stroke-preventing mechanisms:
1) Improves nitric oxide production in endothelial cells and aids to signal to relax muscles and enhance blood distribution***.
 2) Inhibits TNF-a (tumor necrosis factor alpha) and reduces the risk of an artery-blocking clot that produces a stroke****.
L-Theanine protects the body from the damage after the abrupt loss of circulation during the stroke. Animal studies show that administration of L-Theanine up to 12 hours after a stroke protects brain cells and reduces the size of the damaged brain areas.*****
4. L-Theanine prevents damage to brain cells induced by aluminum******.  


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* Nathan PJ, Lu K, Gray M, et al.  The neuropharmacology of L-theanine (N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent.  J Herb Pharmacother.  2006;6(2):21-30
**Kandimalla R, Vallamkondu J, Corgiat EB, et al.  Understanding Aspects of aluminum exposure in Alzhemimer's disease development.  Brain Pathol.  2015.
***Siamwala JH, Dias PM, Majumder S, et al. L-theanine promotes nitric oxide production in endothelial cells throught eNOS phosphorylation.  J Nutr Biochem. 2013;24(3):595-605
****Yamagata K, Xie Y, Suzuki S. etal.  Epigallocatehin-3-gallate inhibits VCAM-1 expression and apoptosis induction associated with LC3 expressions in TNFalpha-stimulated human endothelial cells.  Phytomedicine.  2015;22(4):431-7
*****Zukhurova M, Prosvirnina M, Daineko A, et al.  L-Theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion.  Phytother Res.  2013;27(9):1282-7
*****Sumathi T, Shobana C, Thangarajeswari M, et al.  Protective effect of L-Theanine agianst aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain - histopahological, and biochemical approach.  Drug Chem Toxicol.  2015;38(1):22-31
Disclaimer:  The above statement has not been evaluated by FDA.  It is not intended to diagnose, prevent, treat, and cure any diseases